Nope, not avoidable.
That needs to change in the developers note to make it clear, this is absolutely a "MC will be a SUB to Futa" game and needs to embrace and celebrate it.
Just following the My Life main path, MC's getting sissified and then anally raped by Zeona. There's no choice there. You go find the key to the cock cage you've been put in, you have to blow Calista, again, no choice there.
You can't get back to the slums until your progress Lana and give her a thigh job.
Then you've got to handle a train of Futa in the bathroom gloryholes. Nothing avoidable about that either.
I'm not suggesting any change to the game itself, just to how it's described in the OP.