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Basically Chromium (Google Chrome core) + Node.js.
RPG Maker MV,
Visual Novel Maker and
Tyranobuilder are built on top of it.
Yes, you can use CheatEngine, but there are other solutions to edit the variables. For instance, for MV, there is a particular plugin.
Also, if you launch the game through NW.js SDK and you press the F12 key, you can edit the variables on run-time through the JS console.