Well, I must admit I'm not really sure what you're looking for, but I can mention a couple you could try out.
First off there's "Cloud Meadow", where you have the option to play as a female character and you get to operate your own farm, but it's really early in development and has more than a few bugs as well. (It basically features sexual scenes with monsters, but the story seems to be really interesting.)
Then there's one that revolves around homosexual activities and you play as a male. Basically you're a guy that gets trapped in a dimension with animals instead of humans (as in they speak and they act like humans would). But I can't remember the name of it sadly. (It was honestly one of the few games I played through solely for the story and that says a lot since I'm basically only interested in boobs and asses xD)
Then we have "Good Girl Gone Bad", which as I can see has already been sugested, so I'll move on.
And last but not least there's "Mutiny". It's a game where, due to certain circumstances, you become the captain of a ship. You play as a female protagonist going by the name "Grace". The main focus of the game is to help out your crew "grow" as people. Most of the characters are futas and all of them (except Grace) are part animals. (Fair warning, if you're not into beastiality you should better avoid this one, since some of the crew's genitals are animal ones and they are depicted pretty accurately.)
If you're interested I could share a bunch more games you could try, yet not many of them would be "female friendly". If you do, message me, I would be more than happy to talk about my past experiences with the games I've played. :3
