Can this mod be played for the NTR while the sissification/trans/diaper stuff can be avoided??
Pretty much everything can be avoided. The trans content is from the normal game, where it's avoidable. You choose whether Eve is cis or trans.
The diaper content can only be enabled in the cheat menu.
There isn't really any sissification. In the normal game, there are a number of places where you can choose a dominant or submissive response to Jenny. The worst that can happen in the mod, if you go the submissive route, is that she makes Anon wear panties. You can always switch him back to briefs in the cheat menu.
That said, don't play the mod for the NTR, because it's also minimal and avoidable. Play the mod for the SPH. Everything else is just an extension of the fact that the MC has a small penis. If you want the MC to have a small penis, you may also be into other femdom fetishes, like cuckolding/NTR, chastity, sissification, or diapers, so those related fetishes are included in small, avoidable quantities. You can be into SPH without being into all, or any, of the others, so they're all just bonus content. We're all here for the SPH, and that's the only thing you're going to get a lot of in this mod.
Get Roxxy to titfuck you in her trailer, then tell her to ask her question, tell her it's just about sex, and tell her that she can sleep with other men.